Here grace subsumes nauture - there is nothing natural in this twelfth century icon.
In Van Eyck's Madonna of the Chancellor Rolin (1435) Rolin is facing Mary and he is the same size: there is a battle between nature and grace - no side is dominant.
In Fouquet's painting the king's mistress is painted as Mary with one breast exposed - nature has swallowed grace.
Schaeffer points out:
... when nature is made autonomous it is destructive. As soon as one allows an autonomous realm one finds that the lower element begins to eat up the higher.The Christians worldview knows nothing of dualism - there is no battle between nature and grace - no one aspect is greater than the other. In the Christian worldview grace restores nature.